   
|
 |
| Neuroscience Homepage > Faculty List
> Yuan | |
LiLian
Yuan, Ph.D
Assistant Professor, Department of Neuroscience
yuanx033@umn.edu |
|
 Dendritic function in neuronal
information processing.
Dendrites are highly branched
structures and may account for up to more than 90% of the postsynaptic
surface of a neuron. Because
dendritic processes provide the substrate for receiving and integrating
incoming information, they are critically important for controlling
neuronal output. With
the ability to
directly measure electrical and calcium signals from the dendrites, we
have learned a great deal about their active properties in the
information process over the past ten years.
An
increasing amount of evidence also indicates that abnormal dendritic
growth and spine formation are the most consistent anatomic findings in
mental retardation, such as Alzheimer's disease and Fragile X syndrome. My
research focuses on understanding dendritic mechanisms underlying
synaptic and intrinsic plasticity, and how
the malfunction of these mechanisms contributes to human neurological
diseases. Major
techniques employed in my laboratory include dendritic patch recordings
in acute slices and organotypic culture, Ca imaging, transgenic mice,
in vitro gene expression via vial infection, and immunohistochemistry. |
| Selected Publications
|  | Chen
X, Yuan LL, Zhao C, Birnbaum SG, Frick A, Jung WE, Schwarz TL, Sweatt
JD, Johnston D.
Deletion of Kv4.2 gene eliminates dendritic
A-type K+ current and
enhances induction of long-term potentiation in hippocampal CA1
pyramidal neurons.
J
Neurosci. 2006 Nov 22;26(47):12143-51. | | Lauver
A, Yuan LL, Jeromin A, Nadin BM, Rodriguez JJ, Davies HA, Stewart MG,
Wu GY, Pfaffinger PJ.
Manipulating Kv4.2 identifies a specific
component of hippocampal pyramidal neuron A-current that depends upon
Kv4.2 expression.
J
Neurochem. 2006 Nov;99(4):1207-23. Epub 2006 Oct 5. |
| Yuan LL, Chen X.
Diversity
of potassium channels in neuronal dendrites.
Prog
Neurobiol. 2006 Apr;78(6):374-89. Epub 2006 May 22. Review. |
| Yuan
LL, X Chen, K Kunjil, P Pfaffinger, and D Johnston. Increase in the
rate of inactivation of expressed and native A-type K + channels by a
MEK inhibitor. Am J Physiol (In press)
| | Varga AW *, LL Yuan *,
AE Anderson, L Schrader, G-Y Wu, D. Johnston, JD Sweatt (2004). CaMKII modulates Kv4.2 channel
expression and upregulates neuronal A-type potassium current. J.
Neuroscience. 24: 3643-3654
*Co-first authors | | Yuan LL, JP Adams, M Swank, JD Sweatt and D Johnston
(2002). Protein
kinase modulation of dendritic transient K channels in hippocampus
involves a MAPK pathway.
J. Neuroscience
22:4860-4868 | | Yuan LL
and Ganetzky BS. (1999). A
glial-neuronal signaling pathway revealed by mutations in a
Neurexin-related protein. Science, Vol 283, 1343-1345 |
|
