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| Neuroscience
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List > Sparber |
Sheldon Sparber, Ph.D.
Professor, Departments of Pharmacology and Psychiatry
sparb001@umn.edu |
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 Neuropsychopharmacology.
Our laboratory carries out studies on the neuropsychopharmacology
of drugs of abuse, with an emphasis upon developmental exposure. We
also study the cognitive, other behavioral, physiological and neurochemical
changes associated with exposure to environmental neurotoxins with
the goal of characterizing their mechanisms of action and/or developing
animal models for Alzheimer's disease and other forms of dementia.
Research and research training are often directed toward discovering
pharmacological and nonpharmacological intervention strategies that
might be effective in blocking or reversing CNS dysfunction resulting
from exposure to drug and chemical insults. |
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Selected Publications
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Schrott LM, Baumgart MI, Zhang X, Sparber SB
Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors.
J Pharmacol Exp Ther. 2002 Oct;303(1):257-64 |
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Schrott LM, Sparber SB.
Embryonic "binge" cocaine exposure alters neural-immune and neural-endocrine
interactions in young chickens: involvement of serotonin(2) receptors.
Brain
Res Dev Brain Res 2001 Sep 23;130(1):99-107 |
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Castelli MC, Venturini L, Sparber SB.
Cocaine and salicylate: documentation of hydroxyl radical formation
in hearts and brains of 18-day-old chick embryos and unexpected interactive
toxicity.
Psychopharmacology
(Berl) 2001 Jun;156(1):23-31 |
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Larson EB, Schrott LM, Bordone L, Sparber SB.
Embryonic cocaine exposure and corticosterone: serotonin(2) receptor
mediation.
Pharmacol
Biochem Behav 2001 May-Jun;69(1-2):71-5 |
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Venturini L, Sparber SB.
Salicylate and cocaine: interactive toxicity during chicken mid-embryogenesis.
Free
Radic Biol Med 2001 Jan 15;30(2):198-207 |
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Schrott LM, Sweeney WA, Bodensteiner KE, Sparber SB
Late embryonic ritanserin exposure fails to alter normal responses
to immune system stimulation in young chicks.
Pharmacol
Biochem Behav 1999 Sep;64(1):81-8 |
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