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| Neuroscience
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Donald A. Simone, Ph.D.
Associate Professor, Department of Psychiatry
simon003@umn.edu |
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 Neural
Mechanism of Pain Sensation.
The general focus of our research is the study of anatomical, physiological,
and pharmacological mechanisms underlying pain sensation. Primary
research interests include neural encoding of cutaneous and muscle
pain. We are interested particularly in the neural mechanisms that
account for hyperalgesia (enhanced sensitivity to pain) following
tissue injury or disease, and the modulation of excitability of sensory
neurons involved in pain transmission. Psychophysical, behavioral,
and electrophysiological techniques are used in parallel. |
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Selected Publications
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Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr.
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
J Neurophysiol. 2004 Jan;91(1):213-22 |
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Hamamoto DT, Simone DA
Characterization of cutaneous primary afferent fibers excited by acetic acid in a model of nociception in frogs.
J Neurophysiol. 2003 Aug;90(2):566-77 |
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Kehl LJ, Hamamoto DT, Wacnik PW, Croft DL, Norsted BD, Wilcox GL, Simone DA.
A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.
Pain. 2003 May;103(1-2):175-86. |
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Turner MS, Hamamoto DT, Hodges JS, Maccecchini ML, Simone DA
SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia.
Brain Res. 2003 May 30;973(2):252-64 |
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Khasabova IA, Simone DA, Seybold VS
Cannabinoids attenuate depolarization-dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
Neuroscience. 2002;115(2):613-25 |
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Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA
Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
J Neurosci. 2002 Oct 15;22(20):9086-98 |
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