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Neuroscience Homepage  > Faculty List > Santi
Peter A. Santi, Ph.D.
Professor, Department of Otolaryngology
psanti@umn.edu

Cochlear Anatomy Laboratory - Lions Research Building

The primary goal of this laboratory is to minimize or prevent hearing loss by improving our understanding of the structure and function of the mammalian inner ear. We are specifically interested in characterizing cochlear glycoconjugates in the normal inner ear and how these macromolecules may be involved in normal hearing and hearing dysfunction in acoustic overstimulation, and Alport's syndrome. We are also developing the first antomical database on the mouse cochlea. The Mouse Cochlea Database (MCD) can be accessed at the following URL: http://mousecochlea.ccgb.umn.edu. An example of a 3D reconstruction is shown in the figure below.

 

The figure at right shows an example of a 3D reconstruction of the mouse cochlea.
Selected Publications
Tsuprun, V. and P. Santi
Structure of outer hair cell stereocilia side and attachment links in the chinchilla cochlea.
J. Histochem Cytochem. 2002;50(4): 493-502
Tsuprun, V. and P. Santi
Proteoglycan arrays in the cochlear basement membrane.
Hear. Res. 2001;157(1-2): 65-76
Tsuprun, V. and P. Santi
Helical structure of hair cell stereocilia tip links in the chinchilla cochlea.
J. Assoc Res Otolaryngol. 2000;1(3): 224-31
Swartz DJ, Santi PA 
Immunolocalization of tenascin in the chinchilla inner ear. 
Hear Res 1999 Apr;130(1-2):108-14
Swartz DJ, Santi PA 
Immunohistochemical localization of keratan sulfate in the chinchilla inner ear. 
Hear Res 1997 Jul;109(1-2):92-101
Mancini PM, Santi PA 
Immunohistochemical localization of the cardiac sodium-calcium exchange protein in the inner ear. 
Ann N Y Acad Sci 1996 Apr 15;779:40
 
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