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| Neuroscience
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Patrick W. Mantyh, Ph.D.
Professor, Department of Preventive Sciences
manty001@umn.edu |
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Cellular and molecular neurobiology.
Currently my laboratory is involved in several research areas.
These include:
1) Exploring what factors regulate glial cells in vivo.
We are particularly interested in defining what specific receptors
glia in vivo express in the normal and injured CNS and what functions
these glial receptors are involved in controlling.
2) Exploring how neuropeptides and growth factors are involved
in regulating inflammation and the immune and wound healing response.
We are also determining whether these factors are involved in the
pathogenesis of inflammatory diseases such as arthritis, asthma
and inflammatory bowel disease.
3) Defining in molecular and cellular terms, how ligands
and their receptors interact to contribute to the sensitization
of primary afferent sensory neurons in inflammatory pain states.
4) Investigating the mechanisms involved in the generation
and maintenance bone cancer pain. By investigating the innervation
of bone, tumor induced bone destruction and/or formation, factors
released by the tumors and correlating that data with neurochemical
changes in peripheral and central nervous systems, we can then propose
mechanistic-based therapies and test therapeutic efficacy in our
established animal model of bone cancer pain.
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Selected Publications
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Goblirsch M, Mathews W, Lynch C, Alaei
P, Gerbi BJ, Mantyh PW, Clohisy DR
Radiation treatment decreases bone cancer pain, osteolysis and tumor
size.
Radiat
Res. 2004 Feb;161(2):228-34 |
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Morcuende S, Gadd CA, Peters M, Moss A, Harris EA,
Sheasby A, Fisher AS, De Felipe C, Mantyh PW, Rupniak NM, Giese KP,
Hunt SP
Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1
receptor gene knockout mice.
Eur
J Neurosci. 2003 Oct;18(7):1828-36 |
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Clohisy DR, Mantyh PW
Bone cancer pain.
Clin
Orthop. 2003 Oct;(415 Suppl):S279-88 |
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Egnaczyk GF, Pomonis JD, Schmidt JA, Rogers SD, Peters
C, Ghilardi JR, Mantyh PW, Maggio JE
Proteomic analysis of the reactive phenotype of astrocytes following
endothelin-1 exposure.
Proteomics.
2003 May;3(5):689-98 |
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Peters CM, Rogers SD, Pomonis JD, Egnaczyk GF, Keyser
CP, Schmidt JA, Ghilardi JR, Maggio JE, Mantyh PW, Egnazyck GF
Endothelin receptor expression in the normal and injured spinal cord:
potential involvement in injury-induced ischemia and gliosis.
Exp
Neurol. 2003 Mar;180(1):1-13 |
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Sabino MAC, Luger NM, Mach DB, Rogers SD, Schwei MJ,
Feia KJ, and Mantyh PW
Different tumors in bone each give rise to a distinct pattern of skeletal
destruction, bone cancer-related pain behaviors and neurochemical
changes in the central nervous system.
International
Journal of Cancer 2003; 104(5):550-8 |
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