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| Neuroscience
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Dezhi Liao, Ph.D.
Associate Professor, Department of Neuroscience
liaox020@umn.edu |
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 Molecular
and Cellular Mechanisms of Synaptic Plasticity.
Activity-dependent modulation of glutamatergic synapses has been suggested
to play important roles in learning and memory in adult brains, and
the formation of synaptic connections in developmental brains.
This modulation is at least partially mediated through the activation
of “silent synapses,” synapses that contain NMDA receptors
but not AMPA receptors. Such synapses are silent at a normal resting
potential due to voltage-dependent magnesium blockade of NMDA receptors.
Our laboratory mainly uses electrophysiological, morphological and
molecular biological techniques to investigate molecular and cellular
mechanisms of activity-dependent synaptic plasticity. Particularly,
we are interested in the cellular mechanisms responsible for the activation
of silent synapses. It has been recently reported that silent
synapses can be rapidly awakened through a rapid acquisition of AMPA
receptors. Our goal is to understand the intracellular signaling
pathways for the rapid synaptic targeting of AMPA receptors. |
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Selected Publications
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El-Kady A, Sun Y, Li YX, Liao DJ. (2011)
Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-κB and Bcl-2 families.
J. Carcinog. 10:24. Epub 2011 Nov 30 |
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Siddique H.R., Liao D.J., Mishra S.K., Schuster T., Wang L., Matter B., Campbell P.M., Villalta P., Nanda S., Deng Y. and Saleem M. (2011)
Epicatechin-rich cocoa polyphenol inhibits kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model.
Int. J. Cancer. 2011 Dec 20. doi: 10.1002/ijc.27409. [Epub ahead of print] |
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Yang M, Sun Y, Ma L, Wang C, Wu JM, Bi A, Liao DJ. (2011)
Complex alternative splicing of the smarca2 gene suggests the importance of smarca2-B variants.
J. Cancer 22: 386-400 |
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Sun Y., Li Y.X., Wu H.J., Wu S.H., Wang Y.A., Luo D.Z. and Liao D.J. (2011)
Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells.
J. Cancer 2: 36-51 |
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Fernandez-Mendoza J., Calhoun S.L., Bixler E.O., Karataraki M., Liao D., Vela-Bueno A., Jose Ramos-Platon M., Sauder K.A., Basta M. and Vgontzas A.N. (2011)
Sleep misperception and chronic insomnia in the general population: role of objective sleep duration and psychological profiles.
Psychosom. Med. 73(1): 88-97 |
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Hoover B.R., Reed M.N., Su J., Penrod R.D., Kotilinek L.A., Grant M.K., Pitstick R., Carlson G.A., Lanier L.M., Yuan L.L., Ashe K.H. and Liao D. (2010)
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.
Neuron 68(6): 1067-81 |
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Kam A.Y., Liao D., Loh H.H. and Law P.Y. (2010)
Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits.
J. Neurosci. 30(45): 15304-16 |
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Zhang Z.M., Whitsel E.A., Quibrera P.M., Smith R.L., Liao D., Anderson G.L. and Prineas R.J. (2009)
Ambient fine particulate matter exposure and myocardial ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative (EEAWHI) study.
Environ. Health Perspect. 117(5): 751-6 |
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Lin H., Higgins P., Loh H.H., Law P.Y. and Liao D. (2009)
Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors.
Neuropsychopharmacology 34(9): 2097-111 |
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Sun Y., Wu J., Wu S.H., Thakur A., Bollig A., Huang Y., Liao D.J. (2009)
Expression profile of microRNAs in c-Myc induced mouse mammary tumors.
Breast Cancer Res. Treat. 118(1): 185-96 |
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Liao D., Grigoriants O.O., Wang W., Wiens K., Loh H.H. and Law P.Y. (2007)
Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors.
Mol. Cell Neurosci. 35(3): 456-69 |
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Liao D., Grigoriants O.O., Loh H.H. and Law P.Y. (2007)
Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons.
J. Neurophysiol. 97(2): 1485-94 |
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Wains K.M., Lin H. and Liao D. (2005)
Rac1 induces the clustering of AMPA receptors during spinogenesis.
J. Neurosci. 25(46): 10627-36 |
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Liao D., Lin H., Law P.Y. and Loh H.H. (2005)
Mu-opioid receptors modulate the stability of dendritic spines.
Proc. Natl. Acad. Sci. USA 102(5): 1725-30 |
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Lin H., Huganir R. and Liao D. (2004)
Temporal dynamics of NMDA receptor-induced changes in spine morphology and AMPA receptor recruitment to spines.
Biochem. Biophys. Res. Commun. 316(2): 501-11. |
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Liao D., Scannevin R.H. and Huganir R. (2001)
Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors.
J. Neurosci. 21(16):6008-17 |
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Ye B., Liao D., Zhang X., Zhang P., Dong H., and Huganir R.L. (2000)
GRASP-1: a neuronal rasGEF associated with the AMPA receptor/GRIP complex.
Neuron 26: 603-617 |
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Liao, D., Zhang, X., O'Brien, R., Ehlers, M. D., and Huganir, R. L. (1999)
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons.
Nat. Neurosci. 2: 37-43 |
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Dong H., Zhang P., Song I., Petralia R.S., Liao D. and Huganir R.L. (1999)
Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2.
J. Neurosci. 19: 6930-41 |
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Kim J.H., Liao D., Lau, L.F. and Huganir, R.L. (1998)
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family.
Neuron 20: 683-691 |
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