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Paul
C. Letourneau, Ph.D.
Professor, Department of Neuroscience
letou001@umn.edu |
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Developmental neurobiology.
Research in Dr. Letourneau's laboratory is directed at understanding
how nerve fibers grow and how the complex circuits of neuronal connections
are formed during embryogenesis. Our goal is to understand how the
intrinsic mechanisms that regulate the motile activity of extending
axons is regulated by extrinsic molecules of the local environment.
These molecules are guidance cues that define the pathways of axonal
growth from neuronal cell bodies to synaptic targets. The methods
we use to pursue this goal include neuronal cell culture, videomicroscopy,
fluorescence microscopy, biochemical analysis of proteins, use of
mutant mice, gene transfection and electroporation.
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Selected Publications
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 | Blackmore M, Letourneau PC.
Changes within maturing neurons limit axonal regeneration in the developing spinal cord.
J Neurobiol. 2006 Mar;66(4):348-60. | | Chen TJ, Gehler S, Shaw AE, Bamburg JR, Letourneau PC.
Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain derived neurotrophic factor.
J Neurobiol. 2006 Feb 5;66(2):103-14. | | Kholmanskikh SS, Koeller HB, Wynshaw-Boris A, Gomez T, Letourneau PC, Ross ME.
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.
Nat Neurosci. 2006 Jan;9(1):50-7. Epub 2005 Dec 20. | | Chen Q, Chen TJ, Letourneau PC, Costa Lda F, Schubert D.
Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth.
J Neurosci. 2005 Jan 12;25(2):281-90. | | Adams DN, Kao EY, Hypolite CL, Distefano MD, Hu WS, Letourneau PC.
Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide.
J Neurobiol. 2005 Jan;62(1):134-47. | | Gehler S, Shaw AE, Sarmiere PD, Bamburg JR, Letourneau PC.
Brain-derived neurotrophic factor regulation of retinal growth cone
filopodial dynamics is mediated through actin depolymerizing
factor/cofilin.
J Neurosci. 2004 Nov 24;24(47):10741-9. |
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Dontchev VD, Letourneau PC.
Growth cones integrate signaling from multiple guidance cues.
J
Histochem Cytochem. 2003 Apr;51(4):435-44 |
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Gallo G, Yee HF Jr, Letourneau PC.
Actin turnover is required to prevent axon retraction driven by endogenous
actomyosin contractility.
J
Cell Biol. 2002 Sep 30;158(7):1219-28 |
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Gallo G, Ernst AF, McLoon SC, Letourneau
PC.
Transient PKA activity is required for initiation but not maintenance
of BDNF-mediated protection from nitric oxide-induced growth-cone
collapse.
J
Neurosci 2002 Jun 15;22(12):5016-23 |
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Pond A, Roche FK, Letourneau PC.
Temporal regulation of neuropilin-1 expression and sensitivity to
semaphorin 3A in NGF-
and NT3-responsive chick sensory neurons.
J
Neurobiol 2002 Apr;51(1):43-53 |
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Gallo G, Letourneau PC.
Neurotrophins and the dynamic regulation of the neuronal cytoskeleton.
J
Neurobiol 2000 Aug;44(2):159-73 |
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