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Steven
Juhn, M.D.
Professor, Department of Otolaryngology
juhnx001@umn.edu |
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Biochemical pathology of inner ear disorders, effects of aging
on auditory system.
Otitis media with mucoid effusion, characterized by mucous cell
metaplasia in the middle ear cleft and thick fluid accumulation
in the middle ear cavity, is a common otological disease that frequently
affects young children. Multiple factors are involved in the development
of this disease, especially middle ear infection and Eustachian
tube dysfunction.
We introduced a three-step method to induce otitis media with effusion
in rats. It was tentatively concluded that inoculation of S. pneumoniae
at 10(7) CFU/ear into the middle ear cavity of rats twice at 2-week
intervals, followed by Eustachian tube obstruction for 8 weeks,
is a promising animal model for otitis media with mucoid effusion,
which may be valuable for studying the human counterpart.
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Selected Publications
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Hunter BA, Lee S, Odland RM, Juhn SK.
Estimation of perilymph concentration of agents applied to the round
window membrane by microdialysis.
Acta
Otolaryngol. 2003 May;123(4):453-8 |
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Bakaletz LO, Juhn SK, Jung TT, Li JD.
Recent advances in otitis media. 5. Molecular biology and biochemistry.
Ann
Otol Rhinol Laryngol Suppl. 2002 Mar;188:52-61 |
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Tsuboi Y, Kim Y, Giebink GS, Le C, Paparella
MM, Chen N, Schachern PA, Juhn SK, Lin J.
Induction of mucous cell metaplasia in the middle ear of rats using
a three-step method: an improved model for otitis media with mucoid
effusion.
Acta
Otolaryngol. 2002 Mar;122(2):153-60 |
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Juhn SK, Hunter BA, Odland RM
Blood-labyrinth barrier and fluid dynamics of the inner ear.
Int
Tinnitus J. 2001;7(2):72-83 |
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Li W, Lin J, Adams GL, Juhn SK.
Expression of inducible nitric oxide synthase (iNOS) in middle ear
epithelial cells by IL-1beta and TNF-alpha.
Int
J Pediatr Otorhinolaryngol. 2000 Sep 29;55(2):91-8 |
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