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Neuroscience Homepage  > Faculty List > Honda
Christopher N. Honda, Ph.D.
Professor, Department of Neuroscience    
Peripheral mechanisms of nociception

The skin and deep tissues comprise a vital interface between our bodies and our surroundings. The senses of touch and pain are especially critical in interactions with our environment. Our research interests are centered on functional and structural mechanisms underlying these senses, and there is a particular emphasis in our laboratory on neuronal mechanisms contributing to the sensory experience of pain.

We use anatomical, immunoistochemical, and electro-physiological techniques to establish relationships between neuronal structure, chemistry and function. We apply these approaches to the study of individual sensory neurons of the peripheral nervous system. Our ain research direction is the functional regulation of peripheral opioid receptors, and how these receptors contribute to peripheral analgesic systems.
Selected Publications
Waataja J.J., Tweden K.S. and Honda C.N. (2011)
Effects of high-frequency alternating current on axonal conduction through the vagus nerve.
J. Neural Eng. 8(5): 056013
Schramm C.L. and Honda C.N. (2010)
Co-administration of δ- and μ-opioid receptor agonists promotes peripheral opioid receptor function.
Pain 151(3): 763-70
Riedl M.S., Braun P.D., Kitto K.F., Roiko S.A., Anderson L.B., Honda C.N., Fairbanks C.A. and Vulchanova L. (2009)
Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
J. Neurosci. 29(42): 13377-88
Wenk, H.N., Brederson, J-D. and Honda, C.N. (2006)
Morphine directly inhibits nociceptors in inflamed skin.
J. Neurophysiol. 5:2083-97
Vulchanova, L. and Honda, C.N. (2005)
Isolectin IB4-mediated cytotoxic targeting of sensory neurons.
In: Molecular Neurosurgery with Targeted Toxins , R.G. Wiley and D.A. Lappi, editors. Humana Press.
Simone D.A., Zhang X., Li J., Zhang J.M., Honda C.N., LaMotte R.H. and Giesler G.J. Jr. (2004)
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
J. Neurophysiol. 91(1): 213-22
Truong H., McGinnis L., Dindo L., Honda C.N. and Giesler G.J. Jr. (2004)
Identification of dorsal root ganglion neurons that innervate the common bile duct of rats.
Exp. Brain Res. 155: 477-84
Wenk H.N. and Honda C.N. (2003)
Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat.
Pain 105(3): 393-401
Stiles J., Honda C.N., Krohne S.G. and Kazacos E.A. (2003)
Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs.
Am. J. Vet. Res. 64(7): 813-8
Wenk H.N., Nannenga M.N. and Honda C.N. (2003)
Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea.
Pain 105(3): 455-65
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