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| Neuroscience
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Christopher N. Honda,
Ph.D.
Professor, Department of Neuroscience
cnhonda.umn.edu
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 Anatomical
and physiological bases of somesthesis, pain.
The skin and deep tissues comprise a vital interface between
our bodies and our surroundings. The senses of touch and pain are
especially critical in our interactions with the environment. Our
research interests are centered on the functional and morphological
mechanisms that underlie the sense of touch, and there is a particular
emphasis in our laboratory on neuronal events and neural pathways
that may contribute to the complex sensory experience of pain.
A combination of various anatomical, immunohisto-chemical, and electrophysiological
techniques are employed to establish basic relationships between neuronal
structure and function. We are applying these techniques to the study
of individual neurons within these sensory systems at the levels of
the spinal cord and the thalamus.
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Selected Publications
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Wenk, H.N., Brederson, J-D, and Honda, C.N. Morphine directly inhibits nociceptors in inflamed skin., J. Neurophysiol. 2006 Apr; 95:2083-97. |
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Vulchanova, L. and Honda, C.N. (2005) Isolectin IB4-mediated cytotoxic targeting of sensory neurons. in Molecular Neurosurgery with Targeted Toxins , R.G. Wiley and D.A. Lappi, editors. Humana Press. |
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Simone DA, Zhang X, Li J, Zhang JM, Honda CN, LaMotte RH, Giesler GJ Jr.
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
J Neurophysiol. 2004 Jan;91(1):213-22 |
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Truong H, McGinnis L, Dindo L, Honda CN, Giesler GJ Jr.
Identification of dorsal root ganglion neurons that innervate the common bile duct of rats. Exp Brain Res. 2004; 155: 477-84. |
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Wenk HN, Honda CN.
Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat.
Pain. 2003 Oct;105(3):393-401 |
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Stiles J, Honda CN, Krohne SG, Kazacos EA
Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs.
Am J Vet Res. 2003 Jul;64(7):813-8 |
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Wenk HN, Nannenga MN, Honda CN
Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea.
Pain. 2003 Oct;105(3):455-65 |
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