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Christopher N. Honda,
Ph.D.
Professor, Department of Neuroscience
cnhonda.umn.edu
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Peripheral mechanisms of nociception
The skin and deep tissues comprise a vital interface between our
bodies and our surroundings. The senses of touch and
pain are especially critical in interactions with our environment.
Our research interests are centered on functional and structural mechanisms underlying these
senses, and there is a particular emphasis in our laboratory
on neuronal mechanisms contributing to the sensory experience of pain.
We use
anatomical, immunoistochemical, and electro-physiological techniques
to establish relationships between neuronal structure, chemistry and
function. We apply these approaches to the study of
individual sensory neurons of the peripheral nervous system. Our ain
research direction is the functional regulation of peripheral opioid
receptors, and how these receptors contribute to peripheral
analgesic systems.
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Selected Publications
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Waataja J.J., Tweden K.S. and Honda C.N. (2011)
Effects of high-frequency alternating current on axonal conduction through the vagus nerve.
J. Neural Eng. 8(5): 056013 |
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Schramm C.L. and Honda C.N. (2010)
Co-administration of δ- and μ-opioid receptor agonists promotes peripheral opioid receptor function.
Pain 151(3): 763-70 |
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Riedl M.S., Braun P.D., Kitto K.F., Roiko S.A., Anderson L.B., Honda C.N., Fairbanks C.A. and Vulchanova L. (2009)
Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
J. Neurosci. 29(42): 13377-88 |
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Wenk, H.N., Brederson, J-D. and Honda, C.N. (2006)
Morphine directly inhibits nociceptors in inflamed skin.
J. Neurophysiol. 5:2083-97 |
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Vulchanova, L. and Honda, C.N. (2005)
Isolectin IB4-mediated cytotoxic targeting of sensory neurons.
In: Molecular Neurosurgery with Targeted Toxins , R.G. Wiley and D.A. Lappi, editors. Humana Press. |
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Simone D.A., Zhang X., Li J., Zhang J.M., Honda C.N., LaMotte R.H. and Giesler G.J. Jr. (2004)
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
J. Neurophysiol. 91(1): 213-22 |
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Truong H., McGinnis L., Dindo L., Honda C.N. and Giesler G.J. Jr. (2004)
Identification of dorsal root ganglion neurons that innervate the common bile duct of rats.
Exp. Brain Res. 155: 477-84 |
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Wenk H.N. and Honda C.N. (2003)
Silver nitrate cauterization: characterization of a new model of corneal inflammation and hyperalgesia in rat.
Pain 105(3): 393-401 |
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Stiles J., Honda C.N., Krohne S.G. and Kazacos E.A. (2003)
Effect of topical administration of 1% morphine sulfate solution on signs of pain and corneal wound healing in dogs.
Am. J. Vet. Res. 64(7): 813-8 |
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Wenk H.N., Nannenga M.N. and Honda C.N. (2003)
Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea.
Pain 105(3): 455-65 |
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