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| S. Hossein
Fatemi, M.D., Ph.D.
Professor, Department of Psychiatry
causes of schizophrenia and autism.
Dr. Fatemi's research and clinical interests have focused on the
etiology and treatment of schizophrenia and mood disorders. His
primary research interests include molecular causes and studies
of the biological basis of schizophrenia and autism. He is an attending physician
at the University Hospital CL Service working with psychiatry residents
in their training. Dr. Fatemi has a NARSAD established investigator
award, a Stanley Foundation award and a Minnesota Medical foundation
grant for the investigation of the expression of several proteins
in mouse hippocampus following prenatal exposure to influenza and
mapping of the same proteins in the postmortem brains of patients
with schizophrenia. His latest publications include articles in
Molecular Psychiatry, Synapse and Brain Research describing his
data involving prenatal viral infection in mice.
Fig. 2. (above) Concentrations and gel mobilities for Reelin, albumin
and ceruloplasmin in controls, schizophrenics, and subjects with
bipolar disorder and major depression. SDS-PAGE and western blotting
of serum proteins from representative normal control (C3, C5, C6,
C7), schizophrenic (S3, S9, S10, S15), bipolar (B4, B5) and depressed
(D1, D3) subjects are shown. The upper panel demonstrates three
Reelin bands at 410, 330 and 180 kDa. The middle and lower panel
blot patterns represent 30 and 5 g unpurified serum ceruloplasmin
and albumin species per corresponding subject serum subjected to
SDS-PAGE and Western blotting.
|| Shi L, Fatemi SH, Sidwell RW, Patterson PH
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring.
J Neurosci. 2003 Jan 1;23(1):297-302
|| Fatemi SH
The role of Reelin in pathology of autism.
Mol Psychiatry. 2002;7(9):919-20
|| Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices.
Biol Psychiatry. 2002 Oct 15;52(8):805-10
|| Fatemi SH, Halt AR, Realmuto G, Earle J, Kist DA, Thuras P, Merz A
Purkinje cell size is reduced in cerebellum of patients with autism.
Cell Mol Neurobiol. 2002 Apr;22(2):171-5
|| Fatemi SH, Stary JM, Egan EA
Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder.
Cell Mol Neurobiol. 2002 Apr;22(2):139-52
|| Fatemi SH, Emamian ES, Sidwell RW, Kist DA, Stary JM, Earle JA, Thuras P
Human influenza viral infection in utero alters glial fibrillary acidic protein immunoreactivity in the developing brains of neonatal mice.
Mol Psychiatry. 2002;7(6):633-40