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|Robert P. Elde, Ph.D.
Professor, Department of Neuroscience
Dean, College of Biological Sciences
in central and peripheral nervous systems.
Research in my laboratory aims to understand some of the cellular
and molecular mechanisms that underlie neurotransmission. Synaptic
neurotransmission is spatially precise and rapid in time course. In
contrast, non-synaptic neurotransmission is less focal and is slower.
In each case, neurons organize and deliver to the appropriate region
of their plasma membrane the molecular machinery required for neurotransmitter
packaging and release. Similarly, receptors and signal transduction
molecules are delivered to appropriate regions of the plasma membrane
of recipient neurons.
We study models that represent each of these forms of neurotransmission.
In the case of synaptic neurotransmission we have focused on the neurons
that package adenosine triphosphate (ATP) into vesicles and release
it to act upon neurons that express the P2X family of ATP-gated ion
channels. We investigate non-synaptic neurotransmission through out
studies of the packaging and release of the opioid peptides and their
action on neurons that express opioid receptors. Our general approach
is to generate antibodies that recognize transmitters, receptors,
and other molecules involved in neurotransmission, and to use these
antibodies to monitor the trafficking of the molecules in question.
|| Vulchanova L, Olson TH, Stone LS, Riedl MS, Elde R, Honda CN.
Cytotoxic targeting of isolectin IB4-binding sensory neurons.
||Guo A, Simone DA, Stone LS, Fairbanks CA,
Wang J, Elde R.
Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper
regions of the superficial dorsal horn: correlation with a shift from
TrkA to Ret expression by dorsal root ganglion neurons.
J Neurosci 2001 Jul;14(2):293-304
||Kang T, Yi J, Guo A, Wang X, Overall CM, Jiang W, Elde
R, Borregaard N, Pei D.
Subcellular distribution and cytokine- and chemokine-regulated secretion
of leukolysin/MT6-MMP/MMP-25 in neutrophils.
Biol Chem 2001 Jun 15;276(24):21960-8
||O'Donnell AM, Ellis LM, Riedl MS, Elde RP, Mawe GM.
Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive
neurons in the myenteric plexus of guinea pig intestines and sphincter
Comp Neurol 2001 Jan 29;430(1):1-11
||Shuster SJ, Riedl M, Li X, Vulchanova L, Elde R.
The kappa opioid receptor and dynorphin co-localize in vasopressin
magnocellular neurosecretory neurons in guinea-pig hypothalamus.
||Stone LS, Vulchanova L, Riedl MS, Wang J,
Williams FG, Wilcox GL, Elde R.
Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic
receptor immunoreactivity in the rat spinal cord.