   
|
 |
| Neuroscience
Homepage > Faculty
List > El-Fakahany |
|
Esam E. El-Fakahany, Ph.D.
Professor, Departments of Psychiatry, Neuroscience
and Pharmacology
elfak001@umn.edu
|
|
 Neuronal
receptor regulation, receptor coupling to second messengers, aging,
Alzheimer's disease, nitric oxide.
This laboratory focuses on investigating the molecular mechanisms
of coupling of neuronal neurotransmitter receptors to second messenger
signal transduction systems. Particular interests include: the interplay
among increased intracellular calcium, activation of protein kinases,
and the generation of nitric oxide. The latter messenger plays an
important role in regulation of cerebral blood flow, learning and
memory, and neurodegeneration.
The laboratory is also interested in studying feedback regulation
of receptor sensitivity by these various second messengers; and the
effects of medications used in psychiatric disorders and Alzheimer's
disease on second messenger signals in the brain. The laboratory also
investigates the cellular mechanisms of neurodegeneration caused by
the ß-amyloid protein that accumulates in senile plaques of
Alzheimer's brains, and the factors that decrease the concentration
of this neurotoxic peptide in the brain, resulting in neuroprotection. |
|
Selected Publications
|
 |
Grant MK, El-Fakahany EE
Therapeutic interventions targeting the nitric oxide system: Current and potential uses in obstetrics, bone disease and erectile dysfunction.
Life Sci. 2004 Feb 20;74(14):1701-21 |
|
Jakubik J, Tucek S, El-Fakahany EE
Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors.
J Pharmacol Exp Ther. 2004 Jan;308(1):105-10 |
|
Linden DR, el-Fakahany EE
Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells.
Neurochem Res. 2002 Jun;27(6):441-9 |
|
Grant MK, Cuadra AE, El-Fakahany EE.
Endogenous expression of nNOS protein in several neuronal cell lines.
Life
Sci 2002 Jul 5;71(7):813-7 |
|
Jakubik J, Tucek S, El-Fakahany EE.
Allosteric modulation by persistent binding of xanomeline of the interaction
of competitive ligands with the M1 muscarinic acetylcholine receptor.
J
Pharmacol Exp Ther 2002 Jun;301(3):1033-41 |
|
Linden DR, El-Fakahany EE.
Microglial derived nitric oxide decreases serotonin content in rat
basophilic leukemia (RBL-2H3) cells.
Eur
J Pharmacol 2002 Feb 1;436(1-2):53-6 |
|
