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| Neuroscience
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Timothy J. Ebner, M.D.,
Ph.D.
Professor and Head, Department of Neuroscience
Max E. and Mary LaDue Pickworth Endowed Chair in Neuroscience
421 Lions Research Building
2001 Sixth St. S.E.
Minneapolis, MN 55455
612-626-2205
ebner001@umn.edu
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Neurophysiology of cerebellum and motor cortex.
Our laboratory is trying to understand how single neurons and populations
of neurons encode the information needed to plan and execute limb
movements. Our goal is to decipher how the brain represents different
movement parameters and then uses this information to control movements.
We are investigating both kinematic and dynamic movement parameters,
recording the activity of neurons in the cerebellum and cerebral
cortex in primates during motor behaviors. A variety of movements
are studied, including reaching to targets in space, tracking moving
targets, the learning of new visuomotor relations, and hand movements.
Using analytical and statistical techniques, we sort out how information
about movement parameters is embedded in the neuronal discharge.
At a higher level of integration, we are interested in how information
in the brain is represented spatially and temporally in populations
of neurons. In the cerebellum we are using flavoprotein fluorescence and Ca++ dyes to visualize neural activity. Using epifluorescence and multi-photon imaging, we are able to construct detailed spatial and
temporal maps of the neuronal activity in the cerebellar cortex.
One major question is to understand the spatial patterns of activity
generated during behavior. We are also using optical imaging to examine the abnormalities in the cerebellar cortex in the spinocerebellar and episodic ataxias.
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Selected Publications
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Pasalar, S., Roitman, A.V., Durfee, W.K., Ebner, T.J.
Effects of force fields on cerebellar Purkinje cell discharge: implications for internal models.
Nat Neurosci. 9(11):1404-11, 2006 |
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Moseley, M.L., Zu, T., Ikeda, Y., Gao, W., Mosemiller, A.K., Daughters, R.S., Chen, G., Weatherspoon, M.R., Clark, H.B., Ebner, T.J., Day, J.W., and Ranum, L.P.
Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.
Nat Genet 38(7):758-769, 2006 |
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Gao, W., Chen, G., Reinert, K.C., and Ebner, T.J.
Cerebellar cortical molecular layer inhibition is organized in parasagittal zones.
J. Neurosci. 26(32):8377-87, 2006 |
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Mason, C.R., Hendrix, C.M., and Ebner, T.J.
Purkinje cells signal hand shape and grasp force during reach-to-grasp in the monkey.
J. Neurophysiol. 95:144-158, 2006 |
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Roitman, A.V., Pasalar, S., Johnson, M.T.V., and Ebner, T.J.
Position, direction of movement, and speed tuning of cerebellar Purkinje cells during circular manual tracking in monkey.
J. Neurosci. 25:9244-9257, 2005 |
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Chen, G., Gao, W., Reinert, K.C., Popa, L.S., Hendrix, C.M., Ross, M.E. and Ebner, T.J. Involvement of Kv1 potassium channels in spreading acidification and depression in the cerebellar cortex.
J Neurophsiol 94: 1287-1298, 2005 |
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Roitman, A.V., Massaquoi, S.G., Takahashi,
K., Ebner, T. J.
Kinematic Analysis of Manual Tracking in Monkeys: Characterization
of Movement Intermittencies during a Circular Tracking Task.
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Neurophysiol. 2004 Feb;91(2):901-11 |
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Ebner, T.J. and Chen, G.
Spreading acidification and depression in the cerebellar cortex.
Neuroscientist
9: 37-45, 2003 |
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Gao, W., Dunbar, R.L., Chen, G., Reinert, K.C., Oberdick,
J., Ebner, T.J.
Optical imaging of long-term depression in the mouse cerebellar cortex
in vivo.
J.
Neuroscience 23: 1859-1866, 2003 |
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