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Neuroscience Homepage  > Faculty List > Ebner

Timothy J. Ebner, M.D., Ph.D.
Professor and Head, Department of Neuroscience
Max E. and Mary LaDue Pickworth Endowed Chair in Neuroscience

421 Lions Research Building
2001 Sixth St. S.E.
Minneapolis, MN 55455

Neurophysiology of cerebellum and motor cortex.

Our laboratory is trying to understand how single neurons and populations of neurons encode the information needed to plan and execute limb movements. Our goal is to decipher how the brain represents different movement parameters and then uses this information to control movements. We are investigating both kinematic and dynamic movement parameters, recording the activity of neurons in the cerebellum and cerebral cortex in primates during motor behaviors. A variety of movements are studied, including reaching to targets in space, tracking moving targets, the learning of new visuomotor relations, and hand movements. Using analytical and statistical techniques, we sort out how information about movement parameters is embedded in the neuronal discharge.

At a higher level of integration, we are interested in how information in the brain is represented spatially and temporally in populations of neurons. In the cerebellum we are using flavoprotein fluorescence and Ca++ dyes to visualize neural activity. Using epifluorescence and multi-photon imaging, we are able to construct detailed spatial and temporal maps of the neuronal activity in the cerebellar cortex. One major question is to understand the spatial patterns of activity generated during behavior. We are also using optical imaging to examine the abnormalities in the cerebellar cortex in the spinocerebellar and episodic ataxias.

Selected Publications
Cramer S.W., Gao W., Chen G. and Ebner T.J. (2012)
Re-evaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.
J. Neurosci. (In Press)
Ebner B.A., Ingram M.A., Barnes J.A., Duvick L.A., Frisch J.L., Clark H.B., Zoghbi H.Y., Ebner T.J. and Orr H.T. (2013)
Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
J. Neurosci. 33(13): 5806-20
Popa L.S., Hewitt A.L. and Ebner T.J. (2012)
Predictive and feedback performance errors are signaled in the simple spike discharge of individual Purkinje cells.
J. Neurosci. 32(44): 15345-58
Hedges V.L., Ebner T.J., Meisel R.L. and Mermelstein P.G. (2012)
The cerebellum as a target for estrogen action.
Front. Neuroendocrinol. 33(4): 403-11
Hewitt A.L., Popa L.S., Pasalar S., Hendrix C.M. and Ebner T.J. (2011)
Representation of limb kinematics in Purkinje cell simple spike discharge is conserved across multiple tasks.
J. Neurophysiol. 106(5): 2232-47
Barnes J.A., Ebner B.A., Duvick L.A., Gao W., Chen G., Orr H.T. and Ebner T.J. (2011)
Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
J. Neurosci. 31(36): 12778-89
Reinert K.C., Gao W., Chen, G., Wang X., Peng Y.P. and Ebner T.J. (2011)
Cellular and metabolic origins of flavoprotein autofluorescence in the cerebellar cortex in vivo.
Cerebellum 10(3): 585-99
Wang X., Chen G., Gao W. and Ebner T.J. (2011)
Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.
J. Neurophysiol. 105(4): 1732-46
Daughters R.S., Tuttle D.L., Gao W., Ikeda Y., Moseley M.L., Ebner T.J., Swanson M.S. and Ranum L.P. (2009)
RNA gain-of-function in spinocerebellar ataxia type 8.
PLoS Genet. 5(8): e1000600. Epub 2009 Aug 14
Hendrix C.M., Mason C.R. and Ebner T.J. (2009)
Signaling of grasp dimension and grasp force in dorsal premotor cortex and primary motor cortex neurons during reach to grasp in the monkey.
J. Neurophysiol. 102(1): 132-45
Wang X., Chen G., Gao W. and Ebner T.J. (2009)
Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo.
Neuroscience 162(3): 713-22
Chen G., Popa L.S., Wang X., Gao W., Barnes J., Hendrix C.M., Hess E.J. and Ebner T.J. (2009)
Low-frequency oscillations in the cerebellar cortex of the tottering mouse.
J. Neurophysiol. 101(1): 234-45
Pasalar S., Roitman A.V., Durfee W.K., Ebner T.J. (2006)
Force field effects on cerebellar Purkinje cell discharge with implications for internal models.
Nat. Neurosci. 9(11): 1404-11
Gao W., Chen G., Reinert K.C., and Ebner T.J. (2006)
Cerebellar cortical molecular layer inhibition is organized in parasagittal zones.
J. Neurosci. 26(32): 8377-87
Mason C.R., Hendrix C.M., and Ebner T.J. (2006)
Purkinje cells signal hand shape and grasp force during reach-to-grasp in the monkey.
J. Neurophysiol. 95: 144-58
Moseley M.L., Zu T., Ikeda Y., Gao W., Mosemiller A.K., Daughters R.S., Chen G., Weatherspoon M.R., Clark H.B., Ebner T.J., Day J.W. and Ranum L.P. (2006)
Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.
Nat. Genet. 38(7): 758-69
Roitman A.V., Pasalar S., Johnson M.T.V., and Ebner T.J. (2005)
Position, direction of movement, and speed tuning of cerebellar Purkinje cells during circular manual tracking in monkey.
J. Neurosci. 25: 9244-57
Chen G., Gao W., Reinert K.C., Popa L.S., Hendrix C.M., Ross M.E. and Ebner T.J. (2005)
Involvement of Kv1 potassium channels in spreading acidification and depression in the cerebellar cortex.
J. Neurophsiol. 94: 1287-98
Roitman A.V., Massaquoi S.G., Takahashi K., Ebner T.J. (2004)
Kinematic Analysis of Manual Tracking in Monkeys: Characterization of Movement Intermittencies during a Circular Tracking Task.
J. Neurophysiol. 91(2): 901-11
Gao W., Dunbar R.L., Chen G., Reinert K.C., Oberdick J. and Ebner T.J. (2003
Optical imaging of long-term depression in the mouse cerebellar cortex in vivo.
J. Neurosci. 23: 1859-66


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