DATE |
TOPIC |
FACULTY |
READING/WORK ASSIGNMENTS |
W, 9/5 |
Course Introduction: Organization, Expectations, & Grading
Lecture 1: Cell Biology of Neurons |
Newman |
chapters 2 & 4 (ch 5, background), PNS |
F, 9/7 |
Lecture 2: Introduction to Cellular Neuroscience |
Newman |
Review previous assignment |
M, 9/10 |
Lecture 3: Gene structure and Cloning Strategies |
Kofuji |
pp 351-403, Molecular Cell Biology |
W, 9/12 |
Lecture 4: Transcription and Study of Gene Function |
Kofuji |
pp 351-403, Molecular Cell Biology, background paper |
F, 9/14 |
8 AM Review Session (Newman and Kofuji)
QUIZ 1
Discussion 1: Dendritic microtubules and cell polarity |
Newman, Nakagawa |
Discussion paper |
M, 9/17 |
Lecture 5: Cellular Electrophysiology I |
Newman |
chapters 6 (pp 105-116), 7, 8, 9 (pp 150-158), PNS |
W, 9/19 |
Lecture 6: Cellular Electrophysiology II
Problem Set 1 distributed. Due 9/29 |
Newman |
Review previous assignment |
F, 9/21 |
Discussion 2: Single Channel Recording |
Newman, Kofuji |
Discussion paper |
M, 9/24 |
DEMONSTRATION 1: MetaNeuron, electrical properties of neurons and axons |
Newman |
pp 152 & 155 PNS |
W, 9/26 |
Lecture 7: Diversity of ion Channels I |
Newman |
chap 9 (pp 158-161), PNS
background paper |
F, 9/28 |
Lecture 8: Diversity of ion Channels II
In Class Discussion: Answers to Problem Set 1
Hand in Problem Set 1 |
Newman |
|
M, 10/1 |
8 AM Review Session (Newman)
QUIZ 2
Discussion 3: Cellular Electrophysiology |
Liao, Yuan |
Discussion paper |
W, 10/3 |
Lecture 9: Voltage-Gated Ion Channels I |
Kofuji |
pp 158-170, PNS
background paper |
F, 10/5 |
Discussion 4: Application of transgenic/knockout technology to neuroscience |
Liao, Nakagawa |
Discussion paper |
M, 10/8 |
Lecture 10: Voltage-Gated Ion Channels II |
Kofuji |
background paper |
W, 10/10 |
Lecture 11: Voltage-Gated Ion Channels III |
Kofuji |
background paper |
Fri, 10/12 |
8 AM Review Session (Kofuji)
QUIZ 3
Discussion 5: Subcellular targeting of ion channels
INDEPENDENT EXPLORATION PROJECT MUST BE APPROVED BY TODAY |
Nakagawa, Kofuji |
Discussion paper
Review pp 88-93 PNS |
M, 10/15 |
Lecture 12: Introduction to synaptic transmission
MIDTERM EXAM distributed. EXAM DUE 10/22, in class |
Dubinsky |
chap 10 (pp 175-186), chap 12 (pp 207-228),
chap 15 (pp 280-1 & 282-294), PNS |
W, 10/17 |
Lecture 13: Quantal release and the role of calcium |
Dubinsky |
chap 14 (pp 253-267 & 274-277), PNS |
F, 10/19 |
Discussion 6: Transmitter release from single synaptic vesicles |
Dubinsky, Liao |
Discussion paper |
M, 10/22 |
Lecture 14: Synaptic vesicle cycles |
Dubinsky |
chap 14 (pp 254-273), PNS; background paper |
W, 10/24 |
Lecture 15: Neurotransmitter recycling |
Dubinsky |
chap 15 (pp 294-296 & 285-287), PNS
background paper |
F, 10/26 |
8 AM Review Session (Dubinsky)
QUIZ 4
Discussion 7: Has the fusion pore protein been found? |
Dubinsky, Masino |
Discussion paper |
M, 10/29 |
Lecture 16: Ligand-Receptor Interactions |
Kofuji |
handout |
W, 10/31 |
Lecture 17: Introduction to Post-Synaptic Processes |
Zirpel |
chapter 11, PNS
background paper |
F, 11/2 |
Lecture 18: Ionotropic Receptors I
DRAFT OF INDEPENDENT EXPLORATION PROJECT DUE |
Zirpel |
chapter 12, PNS
background paper |
M, 11/5 |
Neuroscience Meeting |
|
|
W, 11/7 |
Neuroscience Meeting |
|
|
F,11/9 |
Lecture 19: Ionotropic Receptors II |
Zirpel |
chapter 12, PNS background paper |
M, 11/12 |
8 AM Review Session (Zirpel)
QUIZ 5
Discussion 8: Structure-function of GABAA receptors |
Zirpel, Liao |
Discussion paper |
W, 11/14 |
Lecture 20: Second Messengers, G-Proteins, & Seven-Helix Receptors |
Yuan
|
review chap 10, read chaps 13 & 15, preview chap 63 (pp 1250-1264), PNS;
chap 20, Molecular Cell Biology |
F, 11/16 |
Discussion 9: Localization of glutamate receptors |
Kofuji, Mermelstein |
Discussion paper |
M, 11/19 |
Lecture 21: Second Messenger Pathways |
Yuan |
Review previous assignment |
W, 11/21 |
8 AM Review Session (Yuan)
QUIZ 6
Discussion 10: Opioid receptor trafficking
MEET WITH FACULTY MENTOR BY TODAY TO DISCUSS REVISIONS OF INDEPENDENT EXPLORATION PROJECT |
Yuan, Mermelstein |
Discussion paper |
F, 11/23 |
THANKSGIVING HOLIDAY |
|
|
M, 11/26 |
Lecture 22: Sensory Receptors I |
Zirpel |
chap 21, chap 26 (pp 507-515), chap 29 (pp 572-580), PNS
background paper |
W, 11/28 |
Lecture 23: Sensory Receptors II
INDEPENDENT EXPLORATION PROJECT DUE |
Zirpel |
chap 31, chap 32 (pp 625-630 & 636-642), PNS
background paper |
F, 11/30 |
Lecture 24: Glia-Neuron Interactions |
Newman |
pp 19-21 PNS
background paper |
M, 12/3 |
8 AM Review Session (Zirpel and Newman)
QUIZ 7
Discussion 11: Olfactory transduction |
Zirpel, Yuan |
Discussion paper |
W, 12/5 |
Lecture 25: Mechanisms of Synaptic Plasticity |
Zirpel |
pp 1247-1259, PNS
background paper |
F, 12/7 |
Lecture 26: Mechanisms of Synaptic Plasticity |
Zirpel |
p 918 & 1259-1279, PNS |
M, 12/10 |
Lecture 27: Mechanisms of Synaptic Plasticity |
Zirpel |
Review previous assignments background paper |
W, 12/12 |
8 AM Review Session (Zirpel)
QUIZ 8
Discussion 12: Hippocampal LTP
FINAL EXAM distributed. EXAM DUE at noon, 12/18, 6-145 Jackson Hall |
Zirpel, Masino |
Discussion paper |
